The MCU Monoclonal Antibody is a cutting-edge research tool designed for scientists studying the mitochondrial calcium uniporter (MCU) protein. This antibody, developed through monoclonal antibody technology, exhibits high specificity and sensitivity for detecting MCU in various biological samples.The MCU protein is a key player in mitochondrial calcium uptake, a process essential for cellular bioenergetics and signaling. Dysregulation of MCU has been implicated in numerous diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. By targeting MCU with this monoclonal antibody, researchers can gain valuable insights into the mechanisms underlying these pathologies.
Validated for use in immunofluorescence, immunoprecipitation, and other experimental techniques, the MCU Monoclonal Antibody offers versatility for investigating MCU localization, expression levels, and protein interactions. Its application extends to a wide range of research areas, including mitochondrial biology, cell signaling, and disease mechanisms.Unlock the potential of your research with the MCU Monoclonal Antibody and delve deeper into the fascinating world of mitochondrial calcium regulation.
Product Name:
MCU Monoclonal Antibody
SKU:
CAB22525
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 51-170 of human MCU (NP_612366.1).
Enables calcium channel activity; identical protein binding activity; and uniporter activity. Involved in several processes, including positive regulation of mitochondrial calcium ion concentration; positive regulation of mitochondrial fission; and positive regulation of neutrophil chemotaxis. Acts upstream of or within calcium import into the mitochondrion. Located in mitochondrial inner membrane. Is integral component of mitochondrial inner membrane. Part of uniplex complex.
Purification Method:
Affinity purification
Gene ID:
90550
Clone Number:
ARC57879
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MCU antibody (CAB22525) at1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
