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MCP 1 Monoclonal Antibody [YNR-HMCAF] (CPAB0002)

SKU:
CPAB0002
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
YNR-HMCAF
Applications:
IP
WB
ELISA
€660
Frequently bought together:

Description

system_update_alt Datasheet

MCP 1 Monoclonal Antibody [YNR-HMCAF] (CPAB0002)

The MCP-1 Antibody (CPAB0002) is a polyclonal antibody specifically designed for research involving the MCP-1 protein, also known as monocyte chemoattractant protein 1. MCP-1 is a crucial cytokine involved in the recruitment of monocytes to sites of inflammation, playing a key role in the immune response.Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the MCP-1 protein, this antibody enables the detection and analysis of MCP-1 in various cell types, making it ideal for studies in immunology and inflammatory diseases.

Understanding the function of MCP-1 is essential for researching diseases such as atherosclerosis, cancer, and inflammatory conditions. The MCP-1 Antibody provides researchers with a valuable tool for studying the role of MCP-1 in the immune response and its potential as a therapeutic target in various disease contexts.

Product Name: MCP 1 Antibody
Product Sku: CPAB0002
Size: 500μg
Host Species: Mouse
Immunogen: r.Human MCAF
Clone: YNR-HMCAF.
Reactivity: Human
Applications: Immuneprecipitation, Western Blot, ELISA
Purification Method: Ion exchange
Isotype: IgG2a
Background: Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor κB (NFκB). CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.
Synonyms: Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine (C-C motif) ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11.
Storage Buffer: In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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