The MCOLN2 Polyclonal Antibody (CAB18560) is a valuable tool for researchers studying MCOLN2, a protein involved in lysosomal function and calcium signaling. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in various laboratory techniques, including Western blotting.MCOLN2, also known as TRPML2, is a member of the transient receptor potential (TRP) superfamily and plays a crucial role in endolysosomal trafficking and function. Dysregulation of MCOLN2 has been implicated in lysosomal storage disorders and neurodegenerative diseases, making it a promising target for therapeutic interventions.
By using the MCOLN2 Polyclonal Antibody, researchers can effectively detect and analyze MCOLN2 expression in cell lines and tissue samples, furthering our understanding of its biological functions and potential implications in disease pathology. This antibody is ideal for studies in cell biology, neurology, and drug discovery efforts targeting lysosomal dysfunction.
Product Name:
MCOLN2 Rabbit Polyclonal Antibody
SKU:
CAB18560
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-275 of human MCOLN2 (NP_694991.2).
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).
Purification Method:
Affinity purification
Gene ID:
255231
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MCOLN2 Rabbit pAb (CAB18560) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
