The MCM8 Polyclonal Antibody (CAB12922) is a valuable tool for researchers studying MCM8, a key protein involved in DNA replication and repair processes. This antibody, produced in rabbits, is highly specific for detecting MCM8 in human samples, making it an essential reagent for various research applications, including Western blotting.MCM8 is a member of the minichromosome maintenance (MCM) protein family, which plays a crucial role in ensuring genomic stability and fidelity during cell division. Dysregulation of MCM8 has been linked to genomic instability and cancer development, making it a promising target for cancer research and therapeutic interventions.By utilizing the MCM8 Polyclonal Antibody, researchers can accurately detect and analyze MCM8 protein expression levels in different cell types and experimental conditions.
This antibody's high specificity and sensitivity make it a reliable tool for investigating the functional role of MCM8 in DNA replication, repair mechanisms, and the pathogenesis of cancer and other diseases.Overall, the MCM8 Polyclonal Antibody is an essential reagent for researchers interested in unraveling the molecular mechanisms underlying DNA replication and genome integrity, offering valuable insights into potential therapeutic targets for cancer treatment and other genetic diseases.
Product Name:
MCM8 Rabbit Polyclonal Antibody
SKU:
CAB12922
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 591-840 of human MCM8 (NP_115874.3).
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
84515
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MCM8 Rabbit pAb (CAB12922) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
