MCM7 Rabbit Polyclonal Antibody (CAB1138)
- SKU:
- CAB1138
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | MCM7 Rabbit Polyclonal Antibody |
SKU: | CAB1138 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human MCM7 (NP_005907.3). |
Sequence: | MALK DYAL EKEK VKKF LQEF YQDD ELGK KQFK YGNQ LVRL AHRE QVAL YVDL DDVA EDDP ELVD SICE NARR YAKL FADA VQEL LPQY KERE VVNK DVLD VYIE HRLM MEQR SRDP GMVR SPQN QYPA ELMR RFEL YFQG |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3; MCM7 |
Positive Sample: | HeLa,HepG2,NIH/3T3,U-87MG |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 81kDa |
Observed MW: | 81kDa |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 4176 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |