MCM4 Rabbit Monoclonal Antibody (CAB9251)
- SKU:
- CAB9251
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | MCM4 Rabbit Monoclonal Antibody |
SKU: | CAB9251 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 764-863 of human MCM4 (P33991). |
Sequence: | LHRE ALKQ SATD PRTG IVDI SILT TGMS ATSR KRKE ELAE ALKK LILS KGKT PALK YQQL FEDI RGQS DIAI TKDM FEEA LRAL ADDD FLTV TGKT VRLL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21; MCM4 |
Positive Sample: | PC-12,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 97kDa |
Observed MW: | 97kDa |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Purification Method: | Affinity purification |
Gene ID: | 4173 |
Clone Number: | ARC1491 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |