MCM4 Rabbit Polyclonal Antibody (CAB13513)
- SKU:
- CAB13513
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | MCM4 Rabbit Polyclonal Antibody |
SKU: | CAB13513 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human MCM4 (NP_877423.1). |
Sequence: | QMIK LQES PEDM PAGQ TPHT VILF AHND LVDK VQPG DRVN VTGI YRAV PIRV NPRV SNVK SVYK THID VIHY RKTD AKRL HGLD EEAE QKLF SEKR VELL K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21; MCM4 |
Positive Sample: | HeLa,Jurkat,Raji |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 97kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Purification Method: | Affinity purification |
Gene ID: | 4173 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |