MCM3AP Rabbit Polyclonal Antibody (CAB15748)
- SKU:
- CAB15748
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | MCM3AP Rabbit Polyclonal Antibody |
SKU: | CAB15748 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human MCM3AP (NP_003897.2). |
Sequence: | SSFP VSSA VLGE PFQA SKAG VRQG CEEA VSQV EPLP SLMK GLKR KEDQ DRSP RRHG HEPA EDSD PLSR GDHP PDKR PVRL NRPR GGTL FGRT IQDV FKSN KEVG RLGN KEAK KETG FVES AESD HMAI PGGN QSVL APSR IPGV NKEE ETES REKK EDSL RGTP ARQS NRSE STDS LGGL SPSE VTAI QCKN IPDY LNDR TILE NHFG KIAK VQRI FTRR SKKL AVVH FFDH ASAA LARK KGKS LHKD MAIF WHRK KISP NKKP FSLK EKKP GDGE VSPS TEDA PFQH SPLG KAAG RTGA S |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GANP; SAC3; MAP80; PNRIID; MCM3AP |
Positive Sample: | Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, Nucleus envelope, nuclear pore complex, nucleoplasm. |
Calculated MW: | 218kDa |
Observed MW: | 70kDa |
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.
Purification Method: | Affinity purification |
Gene ID: | 8888 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |