MCM3 Rabbit Polyclonal Antibody (CAB1060)
- SKU:
- CAB1060
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | MCM3 Rabbit Polyclonal Antibody |
SKU: | CAB1060 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human MCM3 (NP_002379.2). |
Sequence: | MAGT VVLD DVEL REAQ RDYL DFLD DEED QGIY QSKV RELI SDNQ YRLI VNVN DLRR KNEK RANR LLNN AFEE LVAF QRAL KDFV ASID ATYA KQYE EFYV GLEG SFGS KHVS PRTL TSCF LSCV VCVE GIVT KCSL VRPK VVRS VHYC PATK KTIE RRYS DLTT LVAF PSSS VYPT KDEE NNPL ETEY GLSV YKDH QTIT IQEM PEKA PAGQ LPRS VDVI LDDD LVDK AKPG DRVQ VVGT YRCL PGKK GGYT SGTF RTVL IACN VKQM SKDA QPSF SAED IAKI KKFS KTRS KDI |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | HCC5; P1.h; RLFB; P1-MCM3; MCM3 |
Positive Sample: | HeLa,293T,PC-12,NIH/3T3,COS-1,COS-7 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 91kDa |
Observed MW: | 105kDa |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4172 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |