The MCM2 Polyclonal Antibody (CAB1056) is a valuable tool for researchers studying the DNA replication protein Minichromosome Maintenance Complex Component 2 (MCM2). This antibody is raised in rabbits and specifically targets the MCM2 protein in human samples, allowing for accurate detection and analysis in Western blot applications.MCM2 is a crucial component of the MCM complex involved in DNA replication and cell proliferation. Dysregulation of MCM2 has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention.
This antibody provides researchers with a reliable means of studying MCM2 expression and function in different cell types, particularly in the context of cancer research.Understanding the role of MCM2 in DNA replication and cellular processes is essential for developing targeted therapies and diagnostic tools for cancer and other diseases. The MCM2 Polyclonal Antibody (CAB1056) offers researchers a valuable tool for exploring the functions and mechanisms of MCM2, advancing our knowledge of cell biology and disease pathology.
Product Name:
MCM2 Rabbit Polyclonal Antibody
SKU:
CAB1056
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 360-700 of human MCM2 (NP_004517.2).
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
Purification Method:
Affinity purification
Gene ID:
4171
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MCM2 antibody (CAB1056) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
