MCM10 Rabbit Polyclonal Antibody (CAB7199)
- SKU:
- CAB7199
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | MCM10 Rabbit Polyclonal Antibody |
SKU: | CAB7199 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_877428.1). |
Sequence: | RLEG APAT MTPK LGRG VLEG DDVL FYDE SPPP RPKL SALA EAKK LAAI TKLR AKGQ VLTK TNPN SIKK KQKD PQDI LEVK ERVE KNTM FSSQ AEDE LEPA RKKR REQL AYLE SEEF QKIL KAKS KHTG ILKE AEAE MQER YFEP LVKK EQME EKMR NIRE VKCR VVTC KTCA YTHF KLLE TCVS EQHE YHWH DGVK RFFK CPCG NRSI SLDR LPNK HCSN CGLY KWER DGML KEKT GPKI GGET LLPR GEEH AKFL NSLK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | CNA43; DNA43; IMD80; PRO2249; MCM10 |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 98kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Purification Method: | Affinity purification |
Gene ID: | 55388 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |