The MCL1 Polyclonal Antibody (CAB24435) is specifically designed for research involving MCL1, a key protein involved in regulating cell survival and apoptosis. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the MCL1 protein, this antibody enables the detection and analysis of MCL1 in various cell types, making it an essential tool for studies in cancer research and apoptosis mechanisms.MCL1 is a critical anti-apoptotic protein that plays a vital role in promoting cell survival and protecting cells from death signals. Its dysregulation has been implicated in numerous diseases, including cancer, making it a promising target for therapeutic interventions.
Understanding the expression and function of MCL1 is crucial for developing targeted therapies that can selectively induce cell death in cancer cells while sparing normal cells.Overall, the MCL1 Polyclonal Antibody (CAB24435) is a valuable tool for researchers studying cell survival, apoptosis, and cancer biology. Its high reactivity and specificity make it an excellent choice for studies aiming to elucidate the role of MCL1 in disease pathogenesis and identify potential therapeutic targets.
Product Name:
MCL1 Polyclonal Antibody
SKU:
CAB24435
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MCL1 (NP_068779.1).
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Purification Method:
Affinity purification
Gene ID:
4170
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MCL1 Rabbit pAb (CAB24435) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
