The MCL1 Polyclonal Antibody (CAB0434) is a valuable tool for researchers studying the MCL1 protein, a key regulator of apoptosis and cell survival. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the MCL1 protein, it enables the detection and analysis of MCL1 expression in various cell types, making it ideal for studies in cancer research and drug development.MCL1, a member of the Bcl-2 family of proteins, plays a critical role in regulating cell survival by preventing apoptosis.
Its dysregulation has been implicated in various cancers, making it a promising target for anti-cancer therapies. By studying the expression and activity of MCL1 using this antibody, researchers can gain insights into the mechanisms underlying cancer progression and potentially identify new therapeutic strategies for targeting MCL1 in cancer treatment.
Product Name:
MCL1 Rabbit Polyclonal Antibody
SKU:
CAB0434
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human MCL1 (NP_068779.1).
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Purification Method:
Affinity purification
Gene ID:
4170
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse testis, using MCL1 antibody (CAB0434) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
