The MCL1 Polyclonal Antibody (CAB0250) is a valuable tool for researchers studying the MCL1 protein, a key regulator of apoptosis and cell survival. This antibody, generated in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MCL1 protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for investigations in cancer research and cell biology.MCL1, a member of the Bcl-2 family of proteins, plays a crucial role in controlling cell survival and resistance to apoptosis. Its dysregulation is often associated with cancer development and progression, making it an important target for therapeutic interventions.
By studying the expression and function of MCL1, researchers can gain insight into the mechanisms underlying cancer pathogenesis and identify new opportunities for targeted therapy development.Overall, the MCL1 Polyclonal Antibody (CAB0250) is a valuable tool for scientists interested in unraveling the role of MCL1 in cellular processes and disease states. Its high specificity and sensitivity make it an essential component of any research project aimed at understanding the intricate mechanisms of cell survival and apoptosis regulation.
Product Name:
MCL1 Rabbit Polyclonal Antibody
SKU:
CAB0250
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human MCL1 (NP_068779.1).
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Purification Method:
Affinity purification
Gene ID:
4170
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using MCL1 Rabbit pAb (CAB0250) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
