The MCL1 Monoclonal Antibody (PACO28198) is a valuable tool for researchers studying MCL1, a protein involved in cell survival and apoptosis regulation. This antibody, produced in mice, exhibits high specificity and sensitivity for detecting MCL1 in human samples, making it a reliable choice for Western blot applications. By binding to the MCL1 protein, researchers can easily visualize and analyze its expression in various cell types, offering insight into its role in cancer biology and therapeutic resistance mechanisms.
MCL1, a member of the Bcl-2 family of proteins, is known for its anti-apoptotic function and contribution to tumor cell survival. Its overexpression has been linked to chemotherapy resistance in cancer cells, making it a promising target for cancer therapy research. By investigating the mechanisms of MCL1 regulation and its interactions with other proteins, researchers can develop more effective strategies to overcome drug resistance and enhance the efficacy of cancer treatments.
Antibody Name:
Mcl1 Antibody (PACO28198)
Antibody SKU:
PACO28198
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog protein (1-308AA)
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity.
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1), Mcl1
UniProt Protein Function:
MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.Protein type: Inhibitor; Channel, misc.; Mitochondrial; Apoptosis; Membrane protein, integralCellular Component: cytoplasm; cytosol; integral to membrane; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleusMolecular Function: BH domain binding; BH3 domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activityBiological Process: apoptosis; apoptotic mitochondrial changes; cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; negative regulation of apoptosis; regulation of apoptosis; response to cytokine stimulus
