The MCIDAS Polyclonal Antibody (PAC0466) is a high-quality antibody designed for research involving MCIDAS, a protein essential for DNA replication and cell division. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunofluorescence.MCIDAS, a crucial regulator of DNA replication, is involved in maintaining genomic stability and controlling cell cycle progression. Its function in coordinating DNA synthesis and cell division makes it a key target for studies in cancer research and developmental biology.
By detecting and analyzing the expression of MCIDAS in different cell types, this antibody facilitates research into the mechanisms underlying cell proliferation and genomic integrity.The MCIDAS Polyclonal Antibody is a valuable tool for researchers investigating the role of MCIDAS in DNA replication, cell cycle control, and cellular differentiation. Its high specificity and sensitivity make it an ideal choice for studies aiming to elucidate the molecular mechanisms governing cell division and genomic stability.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO46466 at dilution of 1:100.
Background:
Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1.
Synonyms:
Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas), MCIDAS, IDAS MCI MCIN
UniProt Protein Function:
MCIDAS: Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Belongs to the geminin family. Homodimer. Interacts with GMNN; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerizationChromosomal Location of Human Ortholog: 5q11.2Cellular Component: nucleolus; nucleusMolecular Function: identical protein binding; protein bindingBiological Process: cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of mitotic cell cycle
