The MCFD2 Polyclonal Antibody (CAB10376) is a valuable tool for researchers studying MCFD2, a protein involved in the transport of coagulation factors in the blood. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to MCFD2, researchers can detect and analyze this protein in various cell types, making it ideal for studies in hemostasis and coagulation research.MCFD2 is essential for the proper functioning of the blood coagulation system, playing a crucial role in the transport and secretion of coagulation factors like Factor V and Factor VIII.
Dysregulation of MCFD2 can lead to bleeding disorders and other coagulation-related diseases. Therefore, understanding the role of MCFD2 is important for developing therapies for these conditions.By using the MCFD2 Polyclonal Antibody (CAB10376), researchers can further investigate the function of MCFD2 in health and disease, paving the way for advancements in the treatment of coagulation disorders.
Product Name:
MCFD2 Rabbit Polyclonal Antibody
SKU:
CAB10376
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-146 of human MCFD2 (NP_644808.1).
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
90411
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MCFD2 Rabbit pAb (CAB10376) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
