The MCCC2 Polyclonal Antibody (CAB7990) is a valuable tool for research involving MCCC2, a protein involved in mitochondrial metabolism and energy production. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MCCC2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in metabolic disease, mitochondrial dysfunction, and related research areas.MCCC2, also known as methylcrotonoyl-CoA carboxylase 2, plays a crucial role in the breakdown of amino acids and fatty acids for energy production in mitochondria.
Dysregulation of MCCC2 has been linked to metabolic disorders, neurodegenerative diseases, and cancer. Investigating the function and regulation of MCCC2 is essential for understanding these diseases and developing targeted therapies to address them. The MCCC2 Polyclonal Antibody is a reliable tool for researchers seeking to explore the role of MCCC2 in health and disease.
Product Name:
MCCC2 Rabbit Polyclonal Antibody
SKU:
CAB7990
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 284-563 of human MCCC2 (NP_071415.1).
This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
64087
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MCCC2 Rabbit pAb (CAB7990) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): MOLT-4.Exposure time: 30s.
