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Anti-MCAM Antibody (CAB16916)

SKU:
CAB16916
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
$167 - $503
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Description

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Anti-MCAM Antibody (CAB16916)

The MCAM Polyclonal Antibody (CAB16916) is a valuable tool for researchers studying MCAM, a cell surface protein involved in cell adhesion and migration processes. This rabbit-derived antibody is highly specific to human samples and is validated for use in Western blotting applications. By binding to the MCAM protein, this antibody allows for the detection and analysis of MCAM expression in various cell types, making it an ideal choice for studies in cell biology and cancer research.MCAM, also known as Melanoma Cell Adhesion Molecule, plays a crucial role in promoting tumor cell migration and invasion, making it a promising target for cancer therapy research.

Understanding the function of MCAM can provide insights into cancer progression and metastasis, ultimately aiding in the development of novel anti-cancer treatments. The MCAM Polyclonal Antibody offers researchers a reliable tool for investigating the role of MCAM in cancer biology and other disease contexts.

Antibody Name:Anti-MCAM Antibody
Antibody SKU:CAB16916
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-560 of human MCAM (NP_006491.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-560 of human MCAM (NP_006491.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VNYV SDVR VSPA APER QEGS SLTL TCEA ESSQ DLEF QWLR EETG QVLE RGPV LQLH DLKR EAGG GYRC VASV PSIP GLNR TQLV NVAI FGPP WMAF KERK VWVK ENMV LNLS CEAS GHPR PTIS WNVN GTAS EQDQ DPQR VLST LNVL VTPE LLET GVEC TASN DLGK NTSI LFLE LVNL TTLT PDSN TTTG LSTS TASP HTRA NSTS TERK LPEP ESRG V
Gene ID:4162
Uniprot:P43121
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:57kDa/71kDa
Observed MW:Refer to figures
Anti-MCAM Antibody (CAB16916)Immunohistochemistry - MCAM Rabbit pAb (CAB16916)
Synonyms:MCAM, CD146, MUC18
Background:
UniProt Protein Function:MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: extracellular space; focal adhesion; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Biological Process: anatomical structure morphogenesis; glomerular filtration; angiogenesis; cell adhesion; positive regulation of cell migration

UniProt Code:P43121
NCBI GenInfo Identifier:85681878
NCBI Gene ID:4162
NCBI Accession:P43121.2
UniProt Secondary Accession:P43121,O95812, Q59E86, Q6PHR3, Q6ZTR2,
UniProt Related Accession:P43121
Molecular Weight:646
NCBI Full Name:Cell surface glycoprotein MUC18
NCBI Synonym Full Names:melanoma cell adhesion molecule
NCBI Official Symbol:MCAM  
NCBI Official Synonym Symbols:CD146; MUC18  
NCBI Protein Information:cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen
UniProt Protein Name:Cell surface glycoprotein MUC18
UniProt Synonym Protein Names:Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146
Protein Family:Cell surface glycoprotein
UniProt Gene Name:MCAM  
UniProt Entry Name:MUC18_HUMAN

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