The MCAK Rabbit Monoclonal Antibody (CAB9140) is a valuable tool for researchers studying MCAK, a kinesin superfamily protein involved in microtubule dynamics and cell division. This antibody, produced in rabbits, is highly specific for MCAK in human samples and has been validated for use in Western blotting and immunofluorescence applications. By targeting the MCAK protein, researchers can visualize and analyze its expression and localization in various cell types, providing insights into its role in cellular processes such as mitosis and cell motility.MCAK is known for its role in regulating microtubule dynamics, including depolymerization and severing, which are essential for proper chromosome segregation during cell division.
Dysregulation of MCAK has been linked to defects in mitosis and chromosomal instability, highlighting its importance in maintaining genomic integrity. Studies on MCAK have implications for cancer research, as aberrant expression of MCAK has been associated with tumorigenesis and metastasis.Overall, the MCAK Rabbit Monoclonal Antibody (CAB9140) is a valuable tool for researchers investigating the functions and regulatory mechanisms of MCAK in various biological processes, with potential implications for the development of novel cancer therapies targeting microtubule dynamics.
Product Name:
KIF2C/MCAK Rabbit Monoclonal Antibody
SKU:
CAB9140
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KIF2C/KIF2C/MCAK (Q99661).
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11004
Clone Number:
ARC1447
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KIF2C/KIF2C/MCAK Rabbit mAb (CAB9140) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
