The MC1R Polyclonal Antibody (CAB13152) is a valuable tool for researchers studying the Melanocortin 1 Receptor (MC1R), a protein involved in regulating melanin synthesis and skin pigmentation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.MC1R is known for its role in determining hair and skin color, as well as its involvement in the tanning response to UV radiation. Research on MC1R has also linked mutations in this receptor to an increased risk of skin cancer, particularly melanoma.
By targeting MC1R with this antibody, researchers can investigate the function and expression of this protein in different cell types, providing insights into melanin production and skin cancer susceptibility.Understanding the mechanisms behind MC1R signaling and regulation can lead to the development of new therapies for skin disorders, as well as novel approaches for managing melanoma and other types of skin cancer. The MC1R Polyclonal Antibody offers a critical tool for advancing research in melanin biology and skin health.
Product Name:
MC1 Receptor Rabbit Polyclonal Antibody
SKU:
CAB13152
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-317 of human MC1 Receptor (NP_002377.4).
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Purification Method:
Affinity purification
Gene ID:
4157
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MC1 Receptor antibody (CAB13152) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
