The MBTPS2 Polyclonal Antibody (PACO22411) is a powerful tool for researchers studying MBTPS2, a critical enzyme involved in various cellular processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards MBTPS2 in human samples, making it an excellent choice for Western blot applications. By targeting the MBTPS2 protein, researchers can gain valuable insights into the regulation and function of this enzyme in different cell types, making it an indispensable tool for studies in biology and disease research.MBTPS2, also known as Site-2 protease, plays a crucial role in the processing and activation of key proteins involved in cell signaling and homeostasis.
Dysregulation of MBTPS2 has been associated with various diseases, including cancer, metabolic disorders, and neurodegenerative conditions. Investigating the function of MBTPS2 can provide important clues for developing targeted therapies and interventions for these debilitating diseases. By using the MBTPS2 Polyclonal Antibody, researchers can unlock the mysteries surrounding MBTPS2 and its impact on cellular physiology and pathology.
Antibody Name:
MBTPS2 Antibody (PACO22411)
Antibody SKU:
PACO22411
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:100-1:500
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human MBTPS2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunofluorescence analysis of A549 cells, using MBTPS2 antibody.
Background:
Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
MBTPS2: Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family.Protein type: Membrane protein, multi-pass; Protease; EC 3.4.24.85; Membrane protein, integralChromosomal Location of Human Ortholog: Xp22.12-p22.11Cellular Component: cytoplasm; Golgi membraneMolecular Function: metallopeptidase activityBiological Process: membrane protein intracellular domain proteolysis; positive regulation of transcription factor activityDisease: Ifap Syndrome With Or Without Bresheck Syndrome; Keratosis Follicularis Spinulosa Decalvans, X-linked; Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-linked
UniProt Protein Details:
NCBI Summary:
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]
