The MBTPS2 Antibody (PAC004534) is a polyclonal antibody developed for research purposes related to MBTPS2, a transmembrane protease involved in the processing of various proteins, including sterol regulatory element-binding proteins (SREBPs). This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications. MBTPS2 plays a crucial role in lipid metabolism and regulation of cholesterol biosynthesis, making it a key target for studies in metabolic disorders, cardiovascular diseases, and cancer research. By binding to MBTPS2, this antibody allows for the detection and analysis of the protein in different cell types, offering researchers valuable insights into the mechanisms underlying these diseases.
Understanding the function of MBTPS2 is essential for unraveling its contribution to lipid homeostasis and metabolic regulation, with potential implications for the development of therapeutic strategies targeting dysregulated lipid metabolism in disease settings. This antibody serves as a valuable tool for investigating the roles of MBTPS2 in various cellular processes and disease states, furthering the advancement of research in this field.
Antibody Name:
MBTPS2 Antibody
Antibody SKU:
PACO04534
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human S2P.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
MBTPS2: Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family.Protein type: Membrane protein, multi-pass; Protease; EC 3.4.24.85; Membrane protein, integralChromosomal Location of Human Ortholog: Xp22.12-p22.11Cellular Component: cytoplasm; Golgi membraneMolecular Function: metallopeptidase activityBiological Process: membrane protein intracellular domain proteolysis; positive regulation of transcription factor activityDisease: Ifap Syndrome With Or Without Bresheck Syndrome; Keratosis Follicularis Spinulosa Decalvans, X-linked; Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-linked
UniProt Protein Details:
NCBI Summary:
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]
