The MBTPS1 Polyclonal Antibody (CAB16243) is a valuable tool for researchers studying MBTPS1, a membrane-bound transcription factor site 1 protease involved in the regulation of cellular processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various research applications, especially in Western blotting.MBTPS1 is known to play a crucial role in proteolytic processing of transcription factors and membrane proteins, impacting cell signaling and gene expression. Its dysregulation has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
By using the MBTPS1 Polyclonal Antibody, researchers can detect and study the expression levels of MBTPS1 in different cell types and tissues, providing insights into its function and potential implications in disease pathology.Furthermore, understanding the molecular mechanisms involving MBTPS1 could lead to the development of novel diagnostic tools and targeted therapies for diseases associated with its aberrant activity. The MBTPS1 Polyclonal Antibody is a valuable asset for researchers seeking to unravel the complexities of MBTPS1 biology and its impact on human health.
Product Name:
MBTPS1 Rabbit Polyclonal Antibody
SKU:
CAB16243
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 803-1052 of human MBTPS1 (NP_003782.1).
Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass type I membrane protein.
Calculated MW:
118kDa
Observed MW:
117kDa
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
Purification Method:
Affinity purification
Gene ID:
8720
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MBTPS1 Rabbit pAb (CAB16243) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
