The MBNL3 Polyclonal Antibody (PAC016658) is a valuable tool for researchers studying MBNL3, a RNA-binding protein involved in alternative splicing regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the MBNL3 protein, this antibody allows for accurate detection and analysis in various cell types, enabling detailed research in developmental biology and neurodegenerative diseases.MBNL3, a member of the Muscleblind-like family, plays a critical role in regulating pre-mRNA alternative splicing, making it a key player in gene expression control.
Dysregulation of MBNL3 has been linked to various diseases, including myotonic dystrophy and certain types of cancer. By studying the functions of MBNL3, researchers can gain important insights into disease mechanisms and potentially identify new therapeutic targets for intervention.In summary, the MBNL3 Polyclonal Antibody is a reliable tool for researchers looking to explore the functions and implications of MBNL3 in various biological processes. Its high specificity and accuracy make it a valuable asset in the field of molecular biology and disease research.
Antibody Name:
MBNL3 Antibody (PACO16658)
Antibody SKU:
PACO16658
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human MBNL3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16658(MBNL3 Antibody) at dilution 1/20. (Original magnification: x200).
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16658(MBNL3 Antibody) at dilution 1/20. (Original magnification: x200).
Background:
This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described.
Synonyms:
muscleblind-like splicing regulator 3
UniProt Protein Function:
MBNL3: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Belongs to the muscleblind family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-bindingChromosomal Location of Human Ortholog: Xq26.2Molecular Function: protein bindingBiological Process: regulation of RNA splicing
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
