The MBNL3 Polyclonal Antibody (PAC016657) is a valuable tool for researchers studying the MBNL3 protein, which is involved in regulating alternative splicing and RNA processing. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the MBNL3 protein, this antibody enables researchers to detect and analyze MBNL3 expression in a variety of cell types, making it an essential tool for investigations in the fields of molecular biology and RNA biology.MBNL3 is a member of the muscleblind-like (MBNL) family of RNA-binding proteins, which play crucial roles in the regulation of alternative splicing and other aspects of RNA metabolism.
Dysregulation of MBNL3 has been implicated in a variety of diseases, including myotonic dystrophy and cancer. Understanding the function and expression patterns of MBNL3 is essential for unraveling the molecular mechanisms underlying these diseases and identifying potential therapeutic targets.Overall, the MBNL3 Polyclonal Antibody (PAC016657) is a valuable resource for researchers investigating the role of MBNL3 in health and disease. Its high specificity and sensitivity make it a reliable tool for detecting MBNL3 expression in a variety of experimental settings, and its use is likely to advance our understanding of the intricate regulatory networks governed by the MBNL protein family.
Antibody Name:
MBNL3 Antibody (PACO16657)
Antibody SKU:
PACO16657
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human MBNL3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16657(MBNL3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16657(MBNL3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described.
Synonyms:
muscleblind-like splicing regulator 3
UniProt Protein Function:
MBNL3: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Belongs to the muscleblind family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-bindingChromosomal Location of Human Ortholog: Xq26.2Molecular Function: protein bindingBiological Process: regulation of RNA splicing
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
