MBNL1 Rabbit Monoclonal Antibody (CAB5149)
- SKU:
- CAB5149
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MBNL1 Rabbit Monoclonal Antibody |
SKU: | CAB5149 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 289-388 of human MBNL1 (Q9NR56). |
Sequence: | IPQA VLPP LPKR PALE KTNG ATAV FNTG IFQY QQAL ANMQ LQQH TAFL PPVP MVHG ATPA TVSA ATTS ATSV PFAA TATA NQIP IISA EHLT SHKY VTQM |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | EXP; MBNL; MBNL1 |
Positive Sample: | HepG2,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic granule, Nucleus. |
Calculated MW: | 42kDa |
Observed MW: | 40kDa,42kDa |
This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
Purification Method: | Affinity purification |
Gene ID: | 4154 |
Clone Number: | ARC1199 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |