The MBNL1 Polyclonal Antibody (CAB8054) is a valuable tool for researchers studying MBNL1, a protein involved in alternative splicing and RNA regulation. This antibody, developed using rabbit hosts, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By binding to the MBNL1 protein, this antibody facilitates the detection and analysis of MBNL1 expression in various cell types, enabling deeper insights into its role in RNA processing and disease development.MBNL1 is essential for regulating alternative splicing events in pre-mRNA, influencing the production of multiple protein isoforms.
Dysregulation of MBNL1 has been implicated in a range of diseases, including myotonic dystrophy and cancer. Research into the functions and dysfunctions of MBNL1 is crucial for understanding the molecular mechanisms underlying these conditions and developing targeted therapies.In conclusion, the MBNL1 Polyclonal Antibody (CAB8054) is a reliable instrument for investigating the role of MBNL1 in RNA regulation and disease pathogenesis. Its specificity, sensitivity, and versatility make it a valuable asset for studies in molecular biology, genetics, and biochemistry, with potential applications in cancer research, neurological disorders, and other fields.
Product Name:
MBNL1 Rabbit Polyclonal Antibody
SKU:
CAB8054
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human MBNL1 (NP_997176.1).
This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
Purification Method:
Affinity purification
Gene ID:
4154
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MBNL1 Rabbit pAb (CAB8054) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
