MBNL1 Rabbit Polyclonal Antibody (CAB8054)
- SKU:
- CAB8054
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MBNL1 Rabbit Polyclonal Antibody |
SKU: | CAB8054 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human MBNL1 (NP_997176.1). |
Sequence: | MAVS VTPI RDTK WLTL EVCR EFQR GTCS RPDT ECKF AHPS KSCQ VENG RVIA CFDS LKGR CSRE NCKY LHPP PHLK TQLE INGR NNLI QQKN MAML AQQM QLAN AMMP GAPL QPVP MFSV APSL ATNA SAAA FNPY LGPV SPSL VPAE ILPT APML VTGN PGVP VPAA AAAA AQKL MRTD RLEV CREY QRGN CNRG ENDC RFAH PADS TMID TNDN TVTV CMDY IKGR CSRE KCKY FHPP AHLQ AKIK AAQY QVNQ AAAA QAAA TAAA MTQS AVKS LKRP LEAT FDLG IPQA VLPP LPKR PALE KTNG ATAV FNTG IFQY QQAL ANMQ LQQH TAFL PPVP MVHG ATPA TVSA ATTS ATSV PFAA TATA NQIP IISA EHLT SH |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 |
Synonyms: | EXP; MBNL; MBNL1 |
Positive Sample: | Jurkat,HepG2,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic granule, Nucleus. |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
Purification Method: | Affinity purification |
Gene ID: | 4154 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |