MBD3 Rabbit Polyclonal Antibody (CAB2251)
- SKU:
- CAB2251
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MBD3 Rabbit Polyclonal Antibody |
SKU: | CAB2251 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human MBD3 (NP_001268383.1). |
Sequence: | MERK SPSG KKFR SKPQ LARY LGGS MDLS TFDF RTGK MLMS KMNK SRQR VRYD SSNQ VKGK PDLN TALP VRQT ASIF KQPV TKIT NHPS NKVK SDPQ KAVD QPRQ LFWE KKLS GLNA FDIA EELV KTMD LPKG LQGV GPGC TDET LLSA IASA LHTS TMPI TGQL SAAV EKNP GVWL NTTQ PLCK AFMV TDED IRKQ EELV QQVR KRLE EALM ADML AHVE ELAR DGEA PLDK ACAE DDDE EDEE EEEE EPDP DPE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | MBD3 |
Positive Sample: | Jurkat,K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus. |
Calculated MW: | 33kDa |
Observed MW: | 36kDa |
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.
Purification Method: | Affinity purification |
Gene ID: | 53615 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |