MBD2 Rabbit Polyclonal Antibody (CAB2241)
- SKU:
- CAB2241
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | MBD2 Rabbit Polyclonal Antibody |
SKU: | CAB2241 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-411 of human MBD2 (NP_003918.1). |
Sequence: | DLSS FDFR TGKM MPSK LQKN KQRL RNDP LNQN KGKP DLNT TLPI RQTA SIFK QPVT KVTN HPSN KVKS DPQR MNEQ PRQL FWEK RLQG LSAS DVTE QIIK TMEL PKGL QGVG PGSN DETL LSAV ASAL HTSS APIT GQVS AAVE KNPA VWLN TSQP LCKA FIVT DEDI RKQE ERVQ QVRK KLEE ALMA DILS RAAD TEEM DIEM DSGD EA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | DMTase; NY-CO-41; MBD2 |
Positive Sample: | mouse heart,mouse kidney,rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 43kDa |
Observed MW: | 53kDa |
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 8932 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |