The Max Polyclonal Antibody (CAB0580) is a high-quality research tool specifically designed for studying the Max protein, a transcription factor involved in the regulation of cell growth and differentiation. This antibody is raised in rabbits, ensuring high reactivity and specificity for human samples. Validated for use in Western blot applications, the Max Polyclonal Antibody binds to the Max protein, allowing for accurate detection and analysis in a variety of cell types.Max, part of the Myc-Max-Mad network, plays a crucial role in controlling cell proliferation and differentiation processes. Dysregulation of the Max protein has been implicated in various diseases, including cancer, making it a key target for research in oncology and molecular biology.
By understanding the function and activity of Max, researchers can unravel its role in tumor development and potentially uncover novel therapeutic targets for cancer treatment.Whether studying cell growth pathways, gene expression regulation, or oncogenic mechanisms, the Max Polyclonal Antibody provides researchers with a reliable tool for investigating the role of the Max protein in cellular processes. Its high specificity and sensitivity make it an ideal choice for immunology, cancer research, and molecular biology studies.
Product Name:
MAX Rabbit Polyclonal Antibody
SKU:
CAB0580
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human MAX (NP_002373.3).
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4149
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAX Rabbit pAb (CAB0580) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
