The Matrilysin Polyclonal Antibody (CAB0695) is a vital tool for researchers studying matrilysin, an enzyme involved in tissue remodeling and extracellular matrix degradation. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an excellent choice for a variety of research applications.Matrilysin, also known as matrix metalloproteinase-7 (MMP-7), plays a crucial role in processes such as wound healing, inflammation, and tumor progression. By targeting the matrilysin protein, this antibody allows for the visualization and analysis of its expression in different cell types, providing valuable insights into its function.
With its validated performance in Western blot applications, the Matrilysin Polyclonal Antibody is an indispensable tool for studies in fields such as cancer research, tissue remodeling, and inflammatory disorders. By enabling researchers to investigate the role of matrilysin in these processes, this antibody contributes to the advancement of knowledge and the development of potential therapeutic strategies.
Product Name:
MMP7 Rabbit Polyclonal Antibody
SKU:
CAB0695
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MMP7 (NP_002414.1).
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Purification Method:
Affinity purification
Gene ID:
4316
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MMP7 Rabbit pAb (CAB0695) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
