MMP7 Rabbit Polyclonal Antibody (CAB0695)
- SKU:
- CAB0695
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | MMP7 Rabbit Polyclonal Antibody |
SKU: | CAB0695 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MMP7 (NP_002414.1). |
Sequence: | KNAN SLEA KLKE MQKF FGLP ITGM LNSR VIEI MQKP RCGV PDVA EYSL FPNS PKWT SKVV TYRI VSYT RDLP HITV DRLV SKAL NMWG KEIP LHFR KVVW G |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:100 - 1:500 |
Synonyms: | MMP-7; MPSL1; PUMP-1; MMP7 |
Positive Sample: | HT-29,293T,A-549,Rat uterus |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 30kDa |
Observed MW: | 20-22kDa/28kDa |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Purification Method: | Affinity purification |
Gene ID: | 4316 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |