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MAT2A Monoclonal Antibody [PAT3A2AT] (CPAB0146)

SKU:
CPAB0146
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT3A2AT
Applications:
WB
ELISA
IHC
$179
Frequently bought together:

Description

system_update_alt Datasheet

MAT2A Monoclonal Antibody [PAT3A2AT] (CPAB0146)

The MAT2A Polyclonal Antibody (CPAB0146) is a valuable tool for researchers studying MAT2A, an essential enzyme involved in the biosynthesis of S-adenosylmethionine (SAM), a key methyl donor in numerous cellular processes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MAT2A protein, this antibody allows for the detection and analysis of MAT2A levels in various cell types, making it an ideal choice for studies in biochemistry and cancer research.

MAT2A plays a crucial role in maintaining cellular methylation patterns and gene expression regulation, making it a potential target for therapeutic intervention in diseases such as cancer and liver disorders. Its involvement in SAM production also makes it a candidate for studying metabolic pathways and epigenetic modifications. By understanding the function of MAT2A, researchers can uncover potential strategies for manipulating methyl metabolism and gene regulation in disease settings.

Product Name:MAT2A Antibody
Product Sku:CPAB0146
Size:5μg
Host Species:Mouse
Immunogen:Anti-human MAT2A mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human MAT2A amino acids 1-395 purified from Ecoli.
Clone:PAT3A2AT.
Reactivity:Human
Applications:Western Blot, ELISA, Immunohistochemistry
Purification Method:MAT2A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
Synonyms:MATA2, MATII, SAMS2, MAT-2A, S-adenosylmethionine synthetase isoform type-2, AdoMet synthetase 2, Methionine adenosyltransferase 2, Methionine adenosyltransferase II, MAT2A, AMS2.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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