The MAT1A Polyclonal Antibody (CAB6650) is a valuable tool for research involving MAT1A, a key enzyme in the methionine cycle that plays a crucial role in liver function and metabolism. This antibody, derived from rabbit serum, exhibits high specificity and sensitivity in detecting MAT1A protein in human samples. Validated for use in various applications such as Western blot and immunohistochemistry, it enables researchers to accurately study the expression and localization of MAT1A in different cellular contexts.
MAT1A is essential for maintaining methionine levels and S-adenosylmethionine (SAM) synthesis, which are crucial for DNA methylation, protein synthesis, and other cellular processes. Dysregulation of MAT1A has been linked to liver diseases, cancer, and metabolic disorders, highlighting its significance as a therapeutic target. By using the MAT1A Polyclonal Antibody, researchers can gain insights into the role of MAT1A in these pathologies and explore potential treatment strategies aimed at restoring its function.
Product Name:
MAT1A Rabbit Polyclonal Antibody
SKU:
CAB6650
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-395 of human MAT1A (NP_000420.1).
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
Purification Method:
Affinity purification
Gene ID:
4143
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat liver, using MAT1A Rabbit pAb (CAB6650) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
