The Mast Cell Chymase Rabbit Monoclonal Antibody is a high-quality research tool designed for studying mast cell chymase, a protease enzyme implicated in various physiological and pathological processes. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in applications such as immunohistochemistry and ELISA.Mast cell chymase is a key player in immune responses, tissue remodeling, and inflammation regulation. Its dysregulation has been linked to conditions like asthma, cardiovascular diseases, and cancer. By targeting mast cell chymase, researchers can gain valuable insights into disease mechanisms and potentially develop new therapeutic strategies.
This monoclonal antibody binds specifically to mast cell chymase, enabling accurate detection and quantification in various sample types. Its reliability and specificity make it an ideal tool for researchers in fields such as immunology, oncology, and cardiovascular research. By using this antibody, scientists can further unravel the complex roles of mast cell chymase and its potential as a therapeutic target in human diseases.
This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants.
Purification Method:
Affinity purification
Gene ID:
1215
Clone Number:
ARC0614
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Mast Cell Chymase (CMA1) (CMA1) Rabbit mAb (CAB11480) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
