The MarvelD3 Polyclonal Antibody (PACO60264) is a vital tool for researchers studying the MARVELD3 protein, a key player in cell adhesion and membrane dynamics. This antibody, generated in rabbits, exhibits high specificity and sensitivity when used in Western blot analyses, enabling precise detection of MARVELD3 in various biological samples.MARVELD3, also known as TR and TMEM230, is essential for maintaining cellular integrity and function through its involvement in cell-cell interactions and membrane organization. Its role in regulating processes like cell growth, migration, and signaling makes it a promising target for investigations into developmental biology, cancer progression, and neurological disorders.
By elucidating the mechanisms by which MARVELD3 influences cellular behavior, researchers can uncover new therapeutic strategies for addressing a range of human diseases.In conclusion, the MarvelD3 Polyclonal Antibody (PACO60264) is a valuable resource for researchers seeking to unravel the functions and implications of the MARVELD3 protein in physiological and pathological contexts. Its reliable performance and specificity make it an indispensable tool for advancing our understanding of cellular biology and disease mechanisms.
Antibody Name:
MARVELD3 Antibody (PACO60264)
Antibody SKU:
PACO60264
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human MARVEL domain-containing protein 3 protein (1-189AA)
Immunofluorescence staining of Hela cells with PACO60264 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
As a component of tight junctions, plays a role in paracellular ion conductivity.
Synonyms:
MARVEL domain-containing protein 3, MARVELD3, MRVLDC3
UniProt Protein Function:
MARVELD3: As a component of tight junctions, plays a role in paracellular ion conductivity. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 16q22.2Cellular Component: cytoplasmic vesicle; integral to membrane; tight junctionMolecular Function: mitogen-activated protein kinase kinase kinase binding; protein bindingBiological Process: intercellular junction assembly and maintenance; negative regulation of epithelial cell proliferation; negative regulation of JNK cascade; response to osmotic stress
