The MARVELD2 Polyclonal Antibody (CAB12612) is a powerful tool for researchers studying MARVELD2, a protein involved in intracellular trafficking and membrane dynamics. This antibody, produced in rabbits, shows high specificity for human samples and has been validated for use in immunofluorescence and immunohistochemistry applications. By binding to MARVELD2, this antibody allows for the visualization and analysis of this protein in various cell types, making it a valuable asset for investigations in cell biology and membrane trafficking.MARVELD2, also known as tricellulin, plays a crucial role in the maintenance of cell-cell junctions and the regulation of membrane permeability.
Its involvement in intracellular trafficking pathways suggests a potential role in disease processes related to membrane dynamics and cell signaling. Research on MARVELD2 could provide valuable insights into conditions such as cancer metastasis, inflammatory disorders, and neurodegenerative diseases, where abnormal membrane dynamics play a role in pathogenesis. By studying MARVELD2 with this polyclonal antibody, researchers can uncover novel mechanisms and potential therapeutic targets for these complex diseases.
Product Name:
MARVELD2 Rabbit Polyclonal Antibody
SKU:
CAB12612
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human MARVELD2 (NP_001033692.2).
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
153562
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MARVELD2 Rabbit pAb (CAB12612) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
