The MARS2 Polyclonal Antibody (PACO54150) is a valuable tool for researchers studying MARS2, a key protein involved in mitochondrial function and energy metabolism. This antibody is produced in rabbits and is highly specific for MARS2 in human samples, making it ideal for Western blot analysis.MARS2, also known as methionyl-tRNA synthetase 2, plays a crucial role in the translation of genetic information into proteins within the mitochondria. Dysregulation of MARS2 has been implicated in various diseases, including neurodegenerative disorders and cancer.
By using this antibody, researchers can investigate the expression levels and subcellular localization of MARS2 in different cell types, providing insights into its function and potential therapeutic roles.Overall, the MARS2 Polyclonal Antibody is a reliable tool for researchers interested in understanding the molecular mechanisms underlying mitochondrial biology and its implications for human health. Its high specificity and sensitivity make it a valuable addition to any research project focusing on MARS2 and its role in disease pathology.
Western Blot. Positive WB detected in: K562 whole cell lysate. All lanes: MARS2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 67 kDa. Observed band size: 67 kDa.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO54150 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human prostate tissue using PACO54150 at dilution of 1:100.
MARS2: Belongs to the class-I aminoacyl-tRNA synthetase family.Protein type: Other Amino Acids Metabolism - selenoamino acid; EC 6.1.1.10; Mitochondrial; LigaseChromosomal Location of Human Ortholog: 2q33.1Cellular Component: cytosol; mitochondrial matrixMolecular Function: methionine-tRNA ligase activityBiological Process: methionyl-tRNA aminoacylation; tRNA aminoacylation for protein translationDisease: Combined Oxidative Phosphorylation Deficiency 25; Spastic Ataxia 3, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:
This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014]
