MARK1/MARK2/MARK3/MARK4 Antibody (PACO01042)
- SKU:
- PACO01042
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MARK1/MARK2/MARK3/MARK4 Antibody (PACO01042)
The MARK1/MARK2/MARK3/MARK4 Antibody (PACO01042) is a versatile tool for researchers studying the MARK family of proteins, which play essential roles in regulating cell division, cell polarity, and cell migration. This antibody, produced using cutting-edge technology, targets all four members of the MARK family, allowing for comprehensive analysis in various experimental settings.MARK proteins are key regulators of cellular processes such as microtubule organization and protein distribution within cells. Dysregulation of MARK proteins has been linked to various diseases, including cancer and neurodegenerative disorders, making them attractive targets for therapeutic interventions.
By targeting all four MARK proteins, the PACO01042 Antibody enables researchers to gain a deeper understanding of their functions and contributions to disease pathology.Whether investigating the role of MARK proteins in cell cycle progression or exploring their potential as therapeutic targets, the PACO01042 Antibody provides reliable and specific detection in a range of applications, including Western blotting and immunofluorescence. Its high specificity and sensitivity make it an invaluable tool for advancing our understanding of the MARK family of proteins and their implications in human health and disease.
| Antibody Name: | MARK1/MARK2/MARK3/MARK4 Antibody |
| Antibody SKU: | PACO01042 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat, Monkey |
| Immunogen: | synthesized peptide derived from human MARK1/2/3/4 around the non-phosphorylation site of T215. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MARK1; KIAA1477; MARK; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c; MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affin |
| UniProt Protein Function: | MARK1: a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; CAMK group; CAMKL family; MARK subfamily Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; cytoskeleton; microtubule cytoskeleton; plasma membrane Molecular Function:ATP binding; magnesium ion binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein serine/threonine kinase activity; tau-protein kinase activity Biological Process: cytoskeleton organization and biogenesis; neuron migration; protein amino acid phosphorylation; Wnt receptor signaling pathway |
| UniProt Code: | Q9P0L2 |
| NCBI GenInfo Identifier: | 124056494 |
| NCBI Gene ID: | 4139 |
| NCBI Accession: | Q9P0L2.2 |
| UniProt Secondary Accession: | Q9P0L2,Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251, D3DTB0 D3DTB1, |
| UniProt Related Accession: | Q9P0L2 |
| Molecular Weight: | 84,911 Da |
| NCBI Full Name: | Serine/threonine-protein kinase MARK1 |
| NCBI Synonym Full Names: | microtubule affinity regulating kinase 1 |
| NCBI Official Symbol: | MARK1Â Â |
| NCBI Official Synonym Symbols: | MARK; Par1c; Par-1c  |
| NCBI Protein Information: | serine/threonine-protein kinase MARK1 |
| UniProt Protein Name: | Serine/threonine-protein kinase MARK1 |
| UniProt Synonym Protein Names: | MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | MARK1Â Â |
| UniProt Entry Name: | MARK1_HUMAN |
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