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MARK1/MARK2/MARK3/MARK4 Antibody (PACO01041)

SKU:
PACO01041
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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MARK1/MARK2/MARK3/MARK4 Antibody (PACO01041)

The MARK1/MARK2/MARK3/MARK4 Antibody (PACO01041) is a highly specific and sensitive tool for research involving the MARK family of proteins. These proteins play key roles in regulating cellular processes such as cell division, cell migration, and cell polarity. The antibody is produced in rabbits and has been validated for use in various applications, including Western blot and immunofluorescence.The MARK family of proteins are crucial for maintaining cellular integrity and function, making them important targets for study in a wide range of research areas including cell biology, neurobiology, and cancer research.

By using the MARK1/MARK2/MARK3/MARK4 Antibody, researchers can accurately detect and analyze the expression and localization of these proteins in different cell types and tissues, allowing for a better understanding of their roles and potential therapeutic implications.

Antibody Name:MARK1/MARK2/MARK3/MARK4 Antibody
Antibody SKU:PACO01041
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human MARK1/2/3/4.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MARK1; KIAA1477; MARK; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c; MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affin
UniProt Protein Function:MARK1: a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; CAMK group; CAMKL family; MARK subfamily

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; cytoskeleton; microtubule cytoskeleton; plasma membrane

Molecular Function:ATP binding; magnesium ion binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein serine/threonine kinase activity; tau-protein kinase activity

Biological Process: cytoskeleton organization and biogenesis; neuron migration; protein amino acid phosphorylation; Wnt receptor signaling pathway

UniProt Code:Q9P0L2
NCBI GenInfo Identifier:124056494
NCBI Gene ID:4139
NCBI Accession:Q9P0L2.2
UniProt Secondary Accession:Q9P0L2,Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251, D3DTB0 D3DTB1,
UniProt Related Accession:Q9P0L2
Molecular Weight:84,911 Da
NCBI Full Name:Serine/threonine-protein kinase MARK1
NCBI Synonym Full Names:microtubule affinity regulating kinase 1
NCBI Official Symbol:MARK1  
NCBI Official Synonym Symbols:MARK; Par1c; Par-1c  
NCBI Protein Information:serine/threonine-protein kinase MARK1
UniProt Protein Name:Serine/threonine-protein kinase MARK1
UniProt Synonym Protein Names:MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:MARK1  
UniProt Entry Name:MARK1_HUMAN

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