The MARCO Polyclonal Antibody (CAB10048) is a valuable tool for researchers studying the macrophage receptor with collagenous structure (MARCO) protein. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot analysis. By binding to the MARCO protein, this antibody allows for the detection and analysis of MARCO in different cell types, making it ideal for studies in immunology, inflammation, and infectious diseases research.
MARCO is a scavenger receptor expressed on macrophages that plays a crucial role in the recognition and clearance of pathogens, apoptotic cells, and debris. Its involvement in the immune response and inflammation makes it a promising target for research into diseases such as sepsis, atherosclerosis, and autoimmune conditions. Understanding the function and regulation of MARCO is essential for developing novel therapeutic strategies that target the immune system and improve disease outcomes.
Product Name:
MARCO Rabbit Polyclonal Antibody
SKU:
CAB10048
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human MARCO (NP_006761.1).
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
Purification Method:
Affinity purification
Gene ID:
8685
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MARCO antibody (CAB10048) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
