The MARCKS Polyclonal Antibody (CAB0936) is specifically designed for research involving Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS), a key regulator of actin cytoskeleton dynamics and cell signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding to the MARCKS protein, it enables precise detection and analysis in various cell types, making it an essential tool for studies in cell biology and neuroscience research.MARCKS is known for its involvement in various cellular processes, including cell adhesion, migration, and synaptic plasticity.
Its role in regulating actin dynamics and signal transduction pathways makes it a crucial player in neuronal development and synaptic function. Research on MARCKS is essential for deciphering the mechanisms underlying neuronal plasticity and synaptic transmission, offering insights into neurological disorders and potential therapeutic targets. The MARCKS Polyclonal Antibody provides a valuable means of investigating MARCKS function and its implications in cellular physiology and disease states.
Product Name:
MARCKS Rabbit Polyclonal Antibody
SKU:
CAB0936
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MARCKS (NP_002347.5).
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Purification Method:
Affinity purification
Gene ID:
4082
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat brain, using MARCKS Rabbit pAb (CAB0936) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
