MARCH8 Rabbit Polyclonal Antibody (CAB12962)
- SKU:
- CAB12962
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | MARCH8 Rabbit Polyclonal Antibody |
SKU: | CAB12962 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 232-291 of human MARCH8 (NP_659458.2). |
Sequence: | YNRV IYVQ NCPE TSKK NIFE KSPL TEPN FENK HGYG ICHS DTNS SCCT EPED TGAE IIHV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MIR; CMIR; c-MIR; MARCH8; RNF178; MARCH-VIII |
Positive Sample: | 22Rv1,U-87MG,Mouse testis,Rat testis,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle membrane, Early endosome membrane, Lysosome membrane, Multi-pass membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 33kDa |
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).
Purification Method: | Affinity purification |
Gene ID: | 220972 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |