The March5 Monoclonal Antibody (PACO13515) is a cutting-edge research tool designed for the detection and analysis of the March5 protein. March5, also known as MARCHF5, is a key player in the regulation of mitochondrial homeostasis and has been implicated in various cellular processes, including mitophagy and apoptosis.This monoclonal antibody, generated in mice, offers high specificity and sensitivity in Western blotting and immunofluorescence applications, allowing for accurate and reliable detection of March5 in a variety of samples.
Its versatility makes it ideal for use in studies related to mitochondrial biology, cellular stress response, and the pathogenesis of various diseases.Research investigating the role of March5 in mitochondrial quality control and cell survival has the potential to shed light on the mechanisms underlying neurodegenerative disorders, metabolic diseases, and aging-related conditions. By targeting March5, researchers aim to develop therapeutic strategies that could ultimately improve human health and longevity.
membrane-associated ring finger (C3HC4) 5;MARCH5;FLJ20445;MARCH-V;MITOL;RNF153 ;
UniProt Protein Function:
MARCH5: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.Protein type: Membrane protein, multi-pass; Ubiquitin conjugating system; Ligase; EC 6.3.2.19; Membrane protein, integral; EC 6.3.2.-; Ubiquitin ligaseChromosomal Location of Human Ortholog: 10q23.32-q23.33Cellular Component: endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; endoplasmic reticulum; integral to membraneMolecular Function: GTPase binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activityBiological Process: protein autoubiquitination; protein polyubiquitination
UniProt Protein Details:
NCBI Summary:
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
E3 ubiquitin-protein ligase MARCH5; ring finger protein 153; mitochondrial ubiquitin ligase; membrane-associated RING-CH protein V; membrane-associated RING finger protein 5
UniProt Protein Name:
E3 ubiquitin-protein ligase MARCH5
UniProt Synonym Protein Names:
Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153
