The MAPT Polyclonal Antibody (CAB1103) is a vital tool for researchers studying the microtubule-associated protein tau (MAPT), a protein implicated in various neurodegenerative disorders, including Alzheimer's disease. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MAPT protein, this antibody allows for the accurate detection and analysis of MAPT expression in different cell types, making it an excellent choice for studies in neurobiology and neurodegenerative diseases.
MAPT is a key player in regulating microtubule stability in neurons, and its dysregulation has been linked to the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease and other tauopathies. Understanding the function and regulation of MAPT is essential for developing targeted therapies for neurodegenerative conditions. The MAPT Polyclonal Antibody offers researchers a reliable tool for investigating the role of MAPT in disease pathology and exploring potential treatment strategies.
Product Name:
Tau Rabbit Polyclonal Antibody
SKU:
CAB1103
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 658-758 of human Tau (NP_058519.3).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Tau Rabbit pAb (CAB1103) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
