The MAPT Polyclonal Antibody (CAB0002) is a valuable tool for research involving the microtubule-associated protein tau (MAPT), a key player in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. This antibody, produced in rabbits, shows high reactivity with human samples and has been specifically validated for use in Western blot applications.MAPT is a protein that stabilizes microtubules in neurons and plays a crucial role in maintaining neuronal structure and function. Dysregulation of MAPT has been implicated in the development of neurofibrillary tangles, a hallmark of Alzheimer's disease pathology.
The MAPT Polyclonal Antibody binds to MAPT protein, allowing for its detection and analysis in various cell types and tissues.Research on MAPT is essential for understanding the molecular mechanisms underlying neurodegenerative diseases and developing potential therapeutic strategies. By studying the role of MAPT in neurodegeneration, researchers can gain insights into disease progression and identify novel targets for drug development. The MAPT Polyclonal Antibody is an essential tool for researchers investigating the function and dysfunction of MAPT in neurodegenerative disorders.
Product Name:
Tau Rabbit Polyclonal Antibody
SKU:
CAB0002
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-758 of human Tau (NP_058519.3).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Tau Rabbit pAb (CAB0002) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
