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MAPT Polyclonal Antibody

SKU:
CAB23656
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
€129 - €359
Frequently bought together:

Description

MAPT Polyclonal Antibody (CAB23656)

The MAPT Polyclonal Antibody (AB20064) is a specialized research tool designed for the study of MAPT, a crucial protein in the central nervous system associated with neurodegenerative diseases such as Alzheimer's and Parkinson's. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been rigorously validated for use in Western blot applications. By binding specifically to the MAPT protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential tool for investigations in neurobiology and neurodegenerative disease research.MAPT, also known as microtubule-associated protein tau, plays a vital role in the stabilization and assembly of microtubules in neurons.

Dysregulation of MAPT has been implicated in the pathogenesis of neurodegenerative disorders, making it a key target for therapeutic intervention. By gaining insight into the function and regulation of MAPT, researchers can potentially develop novel treatments for devastating neurological conditions that currently lack effective therapies. The MAPT Polyclonal Antibody provides a valuable resource for advancing our understanding of these debilitating diseases and the development of targeted therapeutics.

Product Name:MAPT Polyclonal Antibody
Product Code:CAB23656
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Mouse liver, Mouse kidney, Rat brain

Enables DNA binding activity; microtubule binding activity; and protein kinase binding activity. Involved in negative regulation of tubulin deacetylation; regulation of cellular response to heat; and regulation of response to DNA damage stimulus. Acts upstream of or within several processes, including adult walking behavior; generation of neurons; and transport along microtubule. Located in several cellular components, including cytoskeleton; glial cell projection; and postsynaptic density. Is expressed in several structures, including gut; nervous system; sensory organ; smooth muscle tissue; and urinary system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau).

Immunogen:Recombinant protein of mouse MAPT.
Sequence:Email for sequence
Synonyms:Tau, Mtapt, PHF-tau
Calculated MW:38kDa
Observed MW:39kDa

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