The MAPRE1 Polyclonal Antibody (CAB2614) is a valuable tool for researchers studying the MAPRE1 protein, which plays a crucial role in microtubule dynamics and cell division. This antibody specifically targets MAPRE1 and is raised in rabbits, ensuring high reactivity with human samples. Validated for use in Western blot applications, the antibody enables precise detection and analysis of MAPRE1 in various cell types.MAPRE1, also known as EB1, is a key regulator of microtubule dynamics, essential for processes such as cell migration, mitosis, and intracellular transport.
Its involvement in these fundamental cellular functions makes it a significant target for investigation in fields like cell biology, cancer research, and neurology. Understanding the function and regulation of MAPRE1 can provide valuable insights into disease mechanisms and potential therapeutic strategies. By utilizing the MAPRE1 Polyclonal Antibody (CAB2614), researchers can further elucidate the role of MAPRE1 in cellular processes, leading to advancements in our understanding of microtubule dynamics and their implications in various biological pathways.
Product Name:
MAPRE1 Rabbit Polyclonal Antibody
SKU:
CAB2614
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 134-268 of human MAPRE1 (NP_036457.1).
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.
Purification Method:
Affinity purification
Gene ID:
22919
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAPRE1 Rabbit pAb (CAB2614) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
