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MAPKBP1 Rabbit Polyclonal Antibody (CAB2626)

SKU:
CAB2626
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-MAPKBP1 Antibody CAB2626
  • Cell Biology Antibodies 8 Anti-MAPKBP1 Antibody CAB2626
  • Cell Biology Antibodies 8 Anti-MAPKBP1 Antibody CAB2626
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MAPKBP1 Rabbit Polyclonal Antibody
SKU:CAB2626
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1).
Sequence:MAVE GSTI TSRI KNLL RSPS IKLR RSKA GNRR EDLS SKVT LEKV LGIT VSGG RGLA CDPR SGLV AYPA GCVV VLFN PRKH KQHH ILNS SRKT ITAL AFSP
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:JNKBP1; NPHP20; JNKBP-1; MAPKBP1
Positive Sample:Mouse liver,Rat liver
Conjugate:Unconjugated
Cellular Localization:cytoplasm, mitotic spindle pole, nucleolus, nucleoplasm
Calculated MW:164kDa
Observed MW:164kDa

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.

Purification Method:Affinity purification
Gene ID:23005
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using MAPKBP1 antibody (CAB2626) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.

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